Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

A molecular understanding of high-density lipoprotein (HDL) will allow a more complete
grasp of its interactions with key plasma remodelling factors and with cell-surface proteins …

Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P),
which maintains vascular integrity. We show that HDL-associated S1P is bound specifically …

Objective—Plasma high-density lipoproteins (HDL) are potent antiatherogenic and anti-
inflammatory particles. However, HDL particles are highly heterogenic in composition, and …

Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P
receptors located on the cell membrane. In the circulation, S1P is distributed to HDL …

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts either as an
intracellular messenger or as a ligand for its membrane receptors. S1P is a normal …

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals.
However, HDL from patients with coronary artery disease undergoes various modifications …

Abstract Sphingosine 1-phosphate (S1P) is a lipid mediator produced from sphingomyelin
by the sequential enzymatic actions of sphingomyelinase, ceramidase, and sphingosine …

Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-
deficient mice (Apom−/−) have∼ 50% reduced plasma S1P levels. There are 5 known S1P …

Numerous epidemiological studies documented an inverse relationship between plasma
high-density lipoprotein (HDL) cholesterol levels and the extent of atherosclerotic disease …