NK cell function regulation by TGF-β-induced epigenetic mechanisms

S Regis, A Dondero, F Caliendo, C Bottino… - Frontiers in …, 2020 - frontiersin.org
TGF-β is a potent immunosuppressive cytokine that severely affects the function of NK cells.
Tumor cells can take advantage of this ability, enriching their surrounding microenvironment …

Liver cirrhosis and immune dysfunction

E Hasa, P Hartmann, B Schnabl - International immunology, 2022 - academic.oup.com
Cirrhosis is end-stage liver disease resulting from various etiologies and is a common cause
of death worldwide. The progression from compensated to decompensated cirrhosis to …

[HTML][HTML] Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis

H Vietzen, SM Berger, LM Kühner, PL Furlano, G Bsteh… - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a demyelinating disease of the CNS. Epstein-Barr virus (EBV)
contributes to the MS pathogenesis because high levels of EBV EBNA 386–405-specific …

Cervical cancer: emerging immune landscape and treatment

L Guo, K Hua - OncoTargets and therapy, 2020 - Taylor & Francis
Immune cells are essential for defending the body's balance and have increasingly been
implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is …

[HTML][HTML] Treatment of relapsing HPV diseases by restored function of natural killer cells

A Lisco, AP Hsu, D Dimitrova, DM Proctor… - … England Journal of …, 2021 - Mass Medical Soc
Human papillomavirus (HPV) infections underlie a wide spectrum of both benign and
malignant epithelial diseases. In this report, we describe the case of a young man who had …

NKG2D natural killer cell receptor—a short description and potential clinical applications

J Siemaszko, A Marzec-Przyszlak, K Bogunia-Kubik - Cells, 2021 - mdpi.com
Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system.
They can recognize transformed or infected cells. NK cells are armed with a set of activating …

New insights on the pathogenesis of Takayasu arteritis: revisiting the microbial theory

JL Espinoza, S Ai, I Matsumura - Pathogens, 2018 - mdpi.com
Takayasu arteritis (TAK) is a chronic vasculitis that mainly affects the aorta, its major
branches, and the pulmonary arteries. Since the description of the first case by Mikito …

MicroRNAs: pleiotropic regulators in the tumor microenvironment

N Yang, S Zhu, X Lv, Y Qiao, YJ Liu… - Frontiers in immunology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs). They are~ 22 nucleotides long and control both …

The repeated administration of resveratrol has measurable effects on circulating T‐cell subsets in humans

JL Espinoza, LQ Trung, PT Inaoka… - Oxidative medicine …, 2017 - Wiley Online Library
Preclinical studies have shown that resveratrol exerts immunomodulatory effects with
potential clinical value in the amelioration of autoimmune disorders and cancer prevention; …

The host-microbe interplay in human papillomavirus-induced carcinogenesis

R Wakabayashi, Y Nakahama, V Nguyen, JL Espinoza - Microorganisms, 2019 - mdpi.com
Every year nearly half a million new cases of cervix cancer are diagnosed worldwide,
making this malignancy the fourth commonest cancer in women. In 2018, more than 270,000 …