RNA sequencing: new technologies and applications in cancer research

M Hong, S Tao, L Zhang, LT Diao, X Huang… - Journal of hematology & …, 2020 - Springer
Over the past few decades, RNA sequencing has significantly progressed, becoming a
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …

Possible role of pineal and extra-pineal melatonin in surveillance, immunity, and first-line defense

RP Markus, KS Sousa… - International Journal of …, 2021 - mdpi.com
Melatonin is a highly conserved molecule found in prokaryotes and eukaryotes that acts as
the darkness hormone, translating environmental lighting to the whole body, and as a …

Pan‐Cancer analyses reveal Genomics and clinical characteristics of the Melatonergic regulators in cancer

J Zhang, H Jiang, K Du, T Xie, B Wang… - Journal of pineal …, 2021 - Wiley Online Library
Melatonin, an endogenous hormone, plays protective roles in cancer. In addition to
regulating circadian rhythms, sleep, and neuroendocrine activity, melatonin functions in …

Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases

PI Liu, AC Chang, JL Lai, TH Lin, CH Tsai, PC Chen… - Oncogene, 2021 - nature.com
Cancer-related bone erosion occurs frequently in bone metastasis and is associated with
severe complications such as chronic bone pain, fractures, and lower survival rates. In …

Histone deacetylase 9 downregulation decreases tumor growth and promotes apoptosis in non‐small cell lung cancer after melatonin treatment

Z Ma, D Liu, S Di, Z Zhang, W Li, J Zhang… - Journal of pineal …, 2019 - Wiley Online Library
Histone deacetylase 9 functions as an oncogene in a variety of cancers, but its role on non‐
small cell lung cancer (NSCLC) has not been reported. Melatonin was proven to possess …

The dark side of daylight: photoaging and the tumor microenvironment in melanoma progression

A Worrede, SM Douglass… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Continued thinning of the atmospheric ozone, which protects the earth from damaging
ultraviolet radiation (UVR), will result in elevated levels of UVR reaching the earth's surface …

Melatonin and gastrointestinal cancers: Current evidence based on underlying signaling pathways

MH Pourhanifeh, S Mehrzadi, M Kamali… - European Journal of …, 2020 - Elsevier
Gastrointestinal (GI) cancers, leading causes of cancer-related deaths, have been serious
challenging human diseases up to now. Because of high rates of mortality, late-stage …

Melatonin‐triggered post‐transcriptional and post‐translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma

YC Wen, YW Lin, CY Chu, YC Yang… - Journal of pineal …, 2020 - Wiley Online Library
A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) family are widely
implicated in tissue remodeling events manifested in cancer development. ADAMTS1, the …

Loss of keratin 23 enhances growth inhibitory effect of melatonin in gastric cancer

L Li, M Lin, J Luo, H Sun, Z Zhang… - Molecular …, 2023 - spandidos-publications.com
To investigate the effect of keratin 23 (KRT23) on the anticancer activity of melatonin (MLT)
against gastric cancer (GC) cells, microarray analysis was applied to screen differentially …

Melatonin as a repurposed drug for melanoma treatment

R Pathipaka, A Thyagarajan, RP Sahu - Medical Sciences, 2023 - mdpi.com
Melanoma is the most aggressive type of skin cancer, with a greater risk of metastasis and a
higher prevalence and mortality rate. This cancer type has been demonstrated to develop …