Sialidases are found in viruses, bacteria, fungi, avians, and mammals. Mammalian
sialidases differ in their specificity, optimum pH, subcellular localization, and tissue …

Despite significant progress in therapy, there remains a lack of substantial evidence
regarding the molecular factors that lead to renal fibrosis. Neuraminidase 4 (NEU4), an …

Mammalian sialidase Neu1 is involved in various physiological functions, including cell
adhesion, differentiation, cancer metastasis, and diabetes through lysosomal catabolism …

The promyelocytic leukemia-retinoic acid receptor α (PML/RARα) is hypothesized to play a
vital role in the pathogenesis of acute promyelocytic leukemia (APL). A previous study has …

Lysosomal desialylation is the initial step in the degradation of sialo-glycopeptides that is
essential for regenerating sialo-glycoconjugates. Neu1 sialidase is the enzyme responsible …

Neu1 is a lysosomal glycosidase that catalyzes the removal of sialic acids from
glycoconjugates. Although Neu1 sialidase is highly conserved among vertebrates, the role …

Edwardsiella tarda is a gram-negative bacterium causing significant economic losses to
aquaculture. E. tarda possesses NanA sialidase which removes sialic acids from α2–3 sialo …

keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) is a minor component of sialic acids
detected in vertebrates, such as human cancer cells, rat liver, and fish tissues. Although the …

Nuclear sialoglycans are minor components in the nucleus, and their biological significance
was not well understood. Recently, Nile tilapia Neu4 sialidase (OnNeu4) was identified and …

Neurogenesis is an important process for the formation of the central nervous system during
ontogenesis. Mammalian sialidases are involved in neurogenesis through desialylation of …