Hydroxyurea—the good, the bad and the ugly

MW Musiałek, D Rybaczek - Genes, 2021 - mdpi.com
Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

Cadmium (II)-Induced Oxidative Stress Results in Replication Stress and Epigenetic Modifications in Root Meristem Cell Nuclei of Vicia faba

A Żabka, K Winnicki, JT Polit, M Wróblewski… - Cells, 2021 - mdpi.com
Among heavy metals, cadmium is considered one of the most toxic and dangerous
environmental factors, contributing to stress by disturbing the delicate balance between …

[HTML][HTML] Allium cepa and Tradescantia pallida bioassays to evaluate effects of the insecticide imidacloprid

YA Rodríguez, CA Christofoletti, J Pedro, OC Bueno… - Chemosphere, 2015 - Elsevier
The indiscriminate use of pesticides has become a serious environmental concern. Of them,
imidacloprid (IMI) is one of the most widely used worldwide. In 2010 in Brazil, 1.934 tonnes …

Genotoxicity of sulcotrione pesticide and photoproducts on Allium cepa root meristem

E Goujon, C Sta, A Trivella, P Goupil, C Richard… - Pesticide Biochemistry …, 2014 - Elsevier
Contamination by toxic agents in the environment has become matters of concern to
agricultural countries. Sulcotrione, a triketone herbicide used to control dicotyledonous …

[HTML][HTML] Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions

A Żabka, N Gocek, K Winnicki, P Szczeblewski… - Cells, 2021 - mdpi.com
Experiments on Vicia faba root meristem cells exposed to 150 µM cadmium chloride (CdCl2)
were undertaken to analyse epigenetic changes, mainly with respect to DNA replication …

Oxidative replication stress induced by long-term exposure to hydroxyurea in root meristem cells of Vicia faba

A Żabka, N Gocek, JT Polit, J Maszewski - Plant Cell Reports, 2024 - Springer
Key message Low concentrations of hydroxyurea, an inhibitor of DNA replication, induced
oxidative and replicative stress in root apical meristem (RAM) cells of Vicia faba. Abstract …

[HTML][HTML] Treatments with Diquat Reveal the Relationship between Protein Phosphatases (PP2A) and Oxidative Stress during Mitosis in Arabidopsis thaliana Root …

A Kelemen, T Garda, Z Kónya, F Erdődi, L Ujlaky-Nagy… - Plants, 2024 - mdpi.com
Reversible protein phosphorylation regulates various cellular mechanisms in eukaryotes by
altering the conformation, activity, localization, and stability of substrate proteins. In …

Epigenetic modifications evidenced by isolation of proteins on nascent DNA and immunofluorescence in hydroxyurea-treated root meristem cells of Vicia faba

A Żabka, N Gocek, JT Polit, J Maszewski - Planta, 2023 - Springer
Main conclusion By implementation of the iPOND technique for plant material, changes in
posttranslational modifications of histones were identified in hydroxyurea-treated root …

Irrigation affects characteristics of narrow-leaved lupin (Lupinus angustifolius L.) seeds

K Winnicki, I Ciereszko, J Leśniewska, AT Dubis… - Planta, 2019 - Springer
Main conclusion While plant irrigation usually increases yield, irrigation also affects seed
characteristics with respect to endoreplication level, chemical composition, number of …

The effects of anti-DNA topoisomerase II drugs, etoposide and ellipticine, are modified in root meristem cells of Allium cepa by MG132, an inhibitor of 26S …

A Żabka, K Winnicki, JT Polit, J Maszewski - Plant Physiology and …, 2015 - Elsevier
Abstract DNA topoisomerase II (Topo II), a highly specialized nuclear enzyme, resolves
various entanglement problems concerning DNA that arise during chromatin remodeling …