Transition metal-mediated formation of C–N bonds is an essential synthetic methodology.
The discovery of the Chan–Lam amination provided a C–N bond forming process that was …

The exceptional versatility of sulfones has been extensively exploited in organic synthesis
across several decades. Since the first demonstration in 2005 that sulfones can participate …

We report the development of an open-source experimental design via Bayesian
optimization platform for multi-objective reaction optimization. Using high-throughput …

General conditions for organic reactions are important but rare, and efforts to identify them
usually consider only narrow regions of chemical space. Discovering more general reaction …

Favorable molecular interactions between group 16 elements have been implicated in
catalysis, biological processes, and materials and medicinal chemistry. Such interactions …

We report an investigation of the Chan–Lam amination reaction. A combination of
spectroscopy, computational modeling, and crystallography has identified the structures of …

Abstract The Suzuki–Miyaura cross-coupling of organoboron nucleophiles with aryl halide
electrophiles is one of the most widely used carbon–carbon bond-forming reactions in …

Pioneering studies by Kuivila, published more than 50 years ago, suggested ipso
protonation of the boronate as the mechanism for base-catalyzed protodeboronation of …

A wide range of aryl boronic 1, 1, 2, 2-tetraethylethylene glycol esters [ArB (Epin) s] were
readily synthesized. Purifying aryl boronic esters by conventional silica gel chromatography …

Azine‐containing biaryls are ubiquitous scaffolds in many areas of chemistry, and efficient
methods for their synthesis are continually desired. Pyridine rings are prominent amongst …