Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …

The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

BACKGROUND & AIMS: Aspirin reduces the incidence of and mortality from colorectal
cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the …

Little is known about metabolic regulation in stem cells and how this modulates tissue
regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its …

AMP-activated protein kinase (AMPK) β1 or β2 subunits are required for assembling of
AMPK heterotrimers and are important for regulating enzyme activity and cellular …