Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

M Levin - Cell, 2021 - cell.com
How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …

[HTML][HTML] Bioelectric signaling in regeneration: mechanisms of ionic controls of growth and form

KA McLaughlin, M Levin - Developmental biology, 2018 - Elsevier
The ability to control pattern formation is critical for the both the embryonic development of
complex structures as well as for the regeneration/repair of damaged or missing tissues and …

The multifaceted role of TMEM16A in cancer

D Crottès, LY Jan - Cell Calcium, 2019 - Elsevier
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

The body electric 2.0: recent advances in developmental bioelectricity for regenerative and synthetic bioengineering

J Mathews, M Levin - Current opinion in biotechnology, 2018 - Elsevier
Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational
control over anatomical structure and function. Recent successes in manipulating cellular …

The secret life of ion channels: Kv1. 3 potassium channels and proliferation

MT Pérez-García, P Cidad… - American Journal of …, 2018 - journals.physiology.org
Kv1. 3 channels are involved in the switch to proliferation of normally quiescent cells, being
implicated in the control of cell cycle in many different cell types and in many different ways …

HERG channel and cancer: a mechanistic review of carcinogenic processes and therapeutic potential

S He, MT Moutaoufik, S Islam, A Persad, A Wu… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The human ether-à-go-go related gene (HERG) encodes the alpha subunit of Kv11. 1, which
is a voltage-gated K+ channel protein mainly expressed in heart and brain tissue. HERG …

Bioelectric control of metastasis in solid tumors

SL Payne, M Levin, MJ Oudin - Bioelectricity, 2019 - liebertpub.com
As the leading cause of death in cancer, there is an urgent need to develop treatments to
target the dissemination of primary tumor cells to secondary organs, known as metastasis …

[HTML][HTML] Glioblastoma quo vadis: Will migration and invasiveness reemerge as therapeutic targets?

F Lefranc, E Le Rhun, R Kiss, M Weller - Cancer treatment reviews, 2018 - Elsevier
Purpose The purpose of the current review is to highlight, on one hand, the fact that the
migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy …

Ion channel conformations regulate integrin-dependent signaling

A Becchetti, G Petroni, A Arcangeli - Trends in cell biology, 2019 - cell.com
Cell-matrix adhesion determines the choice between different cell fates and is accompanied
by substantial changes in ion transport. The greatest evidence is the bidirectional interplay …

Alterations of ion homeostasis in cancer metastasis: Implications for treatment

G Fnu, GF Weber - Frontiers in Oncology, 2021 - frontiersin.org
We have previously reported that metastases from all malignancies are characterized by a
core program of gene expression that suppresses extracellular matrix interactions, induces …