▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …

Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

Valuable information on translation initiation is available from biochemical data and recently
solved structures. We present a detailed description of current knowledge about the …

Initiation of mRNA translation is a major checkpoint for regulating level and fidelity of protein
synthesis. Being rate limiting in protein synthesis, translation initiation also represents the …

Valyl-tRNA synthetase (ValRS) strictly discriminates the cognate L-valine from the larger L-
isoleucine and the isosteric L-threonine by the tRNA-dependent" double sieve" mechanism …

Leucyl-, isoleucyl-and valyl-tRNA synthetases are closely related large monomeric class I
synthetases. Each contains a homologous insertion domain of∼ 200 residues, which is …

The enzymes of the family of tRNA synthetases perform their functions with high precision by
synchronously recognizing the anticodon region and the aminoacylation region, which are …

The incorporation of noncanonical amino acids into recombinant proteins in Escherichia coli
can be facilitated by the introduction of new aminoacyl-tRNA synthetase activity into the …

Development of antimalarial compounds into clinical candidates remains costly and arduous
without detailed knowledge of the target. As resistance increases and treatment options at …

Of all the nonbonded interactions, hydrogen bond, because of its geometry involving polar
atoms, is the most easily recognizable. Here we characterize two interactions involving the …