What went wrong? The flawed concept of cerebrospinal venous insufficiency

JM Valdueza, F Doepp, SJ Schreiber… - Journal of Cerebral …, 2013 - journals.sagepub.com
In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the
central nervous system is associated with multiple sclerosis (MS), coining the term of chronic …

The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variants

K Dolic, AH Siddiqui, Y Karmon, K Marr, R Zivadinov - BMC medicine, 2013 - Springer
The extra-cranial venous system is complex and not well studied in comparison to the
peripheral venous system. A newly proposed vascular condition, named chronic …

Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case …

AL Traboulsee, KB Knox, L Machan, Y Zhao, I Yee… - The Lancet, 2014 - thelancet.com
Background Chronic cerebrospinal venous insufficiency has been proposed as a unique
combination of extracranial venous blockages and haemodynamic flow abnormalities that …

[HTML][HTML] Recommendations for multimodal noninvasive and invasive screening for detection of extracranial venous abnormalities indicative of chronic cerebrospinal …

R Zivadinov, S Bastianello, MD Dake, H Ferral… - Journal of Vascular and …, 2014 - Elsevier
Under the auspices of the International Society for Neurovascular Disease (ISNVD), four
expert panel committees were created from the ISNVD membership between 2011 and …

Prospective randomized trial of venous angioplasty in MS (PREMiSe)

AH Siddiqui, R Zivadinov, RHB Benedict, Y Karmon… - Neurology, 2014 - AAN Enterprises
Objective: We report the results of the investigation of safety and efficacy of venous
angioplasty in patients with multiple sclerosis (MS) with findings of extracranial venous …

Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study

G Comi, MA Battaglia, A Bertolotto… - Multiple Sclerosis …, 2013 - journals.sagepub.com
Background: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a
possible cause of multiple sclerosis (MS). Objectives: The CoSMo study evaluated the …

CCSVI and MS: a statement from the European Society of neurosonology and cerebral hemodynamics

C Baracchini, JM Valdueza, M Del Sette, G Baltgaile… - Journal of …, 2012 - Springer
To systematically review the ultrasonographic criteria proposed for the diagnosis of chronic
cerebrospinal venous insufficiency (CCSVI). The authors analyzed the five ultrasonographic …

“Liberation treatment” for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free

G Tsivgoulis, S Faissner, K Voumvourakis… - Brain and …, 2015 - Wiley Online Library
Background Chronic cerebrospinal venous insufficiency (CCSVI) has recently been
introduced as a chronic state of impaired cerebral or cervical venous drainage that may be …

Multiple sclerosis and CCSVI: a population-based case control study

F Patti, A Nicoletti, C Leone, S Messina, E D'Amico… - 2012 - journals.plos.org
Background Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to
multiple sclerosis (MS). Objective To evaluate the possible association between CCSVI and …

Arterial, venous and other vascular risk factors in multiple sclerosis

Y Karmon, M Ramanathan, A Minagar… - Neurological …, 2012 - Taylor & Francis
Purpose of review: This article reviews vascular risk factors with specific emphasis on lipid
abnormalities reported to be associated with multiple sclerosis (MS). Recent findings: The …