Inflammation and skeletal muscle regeneration: leave it to the macrophages!

B Chazaud - Trends in immunology, 2020 - cell.com
Inflammation is usually considered as harmful; however, it is also necessary for tissue
recovery after injury. Macrophages exert immune and nonimmune functions throughout this …

[HTML][HTML] Regulation of tissue iron homeostasis: the macrophage “ferrostat”

NC Winn, KM Volk, AH Hasty - JCI insight, 2020 - ncbi.nlm.nih.gov
Iron is an essential element for multiple fundamental biological processes required for life;
yet iron overload can be cytotoxic. Consequently, iron concentrations at the cellular and …

A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15

A Patsalos, L Halasz, MA Medina-Serpas… - Journal of Experimental …, 2021 - rupress.org
Muscle regeneration is the result of the concerted action of multiple cell types driven by the
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …

Divergent roles of inflammation in skeletal muscle recovery from injury

EE Howard, SM Pasiakos, CN Blesso… - Frontiers in …, 2020 - frontiersin.org
A transient increase in local pro-inflammatory cytokine expression following skeletal muscle
injury mediates the repair and regeneration of damaged myofibers through myogenesis …

Macrophages play a key role in tissue repair and regeneration

Y Yu, Z Yue, M Xu, M Zhang, X Shen, Z Ma, J Li, X Xie - PeerJ, 2022 - peerj.com
Tissue regeneration after body injury has always been a complex problem to resolve for
mammals. In adult mammals, the repair process after tissue injury is often accompanied by …

Lineage-determining transcription factor-driven promoters regulate cell type-specific macrophage gene expression

G Nagy, D Bojcsuk, P Tzerpos, T Cseh… - Nucleic Acids …, 2024 - academic.oup.com
Mammalian promoters consist of multifarious elements, which make them unique and
support the selection of the proper transcript variants required under diverse conditions in …

TAM kinase signaling is indispensable for proper skeletal muscle regeneration in mice

N Al-Zaeed, Z Budai, Z Szondy, Z Sarang - Cell death & disease, 2021 - nature.com
Skeletal muscle regeneration following injury results from the proliferation and differentiation
of myogenic stem cells, called satellite cells, located beneath the basal lamina of the muscle …

Interplay of heme with macrophages in homeostasis and inflammation

P Pradhan, V Vijayan, F Gueler… - International journal of …, 2020 - mdpi.com
Macrophages are an integral part of the mononuclear phagocyte system that is critical for
maintaining immune homeostasis. They play a key role for initiation and modulation of …

Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage

Z Yuan, J Li, X Zou, C Liu, J Lu, C Ni… - Journal of Cellular …, 2023 - Wiley Online Library
Periodontal bone regeneration is a major challenge in the treatment of periodontitis.
However, the regenerative vitality of periodontal ligament cells (PDLCs) declines in the …

Transcriptional control of macrophage inflammatory shift during skeletal muscle regeneration

G Juban - Seminars in Cell & Developmental Biology, 2021 - Elsevier
Skeletal muscle is a tissue able to fully regenerate after an acute injury. Macrophages play
an essential role during skeletal muscle regeneration. Resolution of inflammation is a crucial …