Post-translational modifications are at the apex of cellular communication and eventually
regulate every aspect of life. The identification of new post-translational modifiers is opening …

Post-translational modifications (PTMs) add a major degree of complexity to the proteome
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …

Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with
intracellular proteins through ufmylation, similar to ubiquitylation. Ufmylation is involved in …

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …

Abstract p53 is the most intensively studied tumour suppressor. The regulation of p53
homeostasis is essential for its tumour-suppressive function,. Although p53 is regulated by …

Protein biogenesis at the endoplasmic reticulum (ER) in eukaryotic cells is monitored by a
protein quality control system named ER-associated protein degradation (ERAD). While …

Ubiquitin fold modifier 1 (UFM1) is a small, metazoan-specific, ubiquitin-like protein modifier
that is essential for embryonic development. Although loss-of-function mutations in UFM1 …

We previously identified 529 proteins that had been reported by multiple different studies to
change their expression level with age in human plasma. In the present study, we measured …

In plants, the endomembrane system is tightly regulated in response to environmental
stresses for maintaining cellular homeostasis. Autophagosomes, the double membrane …

A proper DNA damage response (DDR) is essential to maintain genome integrity and
prevent tumorigenesis. DNA double-strand breaks (DSBs) are the most toxic DNA lesion …