Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Over the last several decades, an impressive array of advanced microscopic and analytical
tools, such as single-particle tracking and nanoscopic fluorescence correlation …

G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their
spatial organization in plasma membrane (PM) domains is believed to encode signaling …

The interaction of lipids and proteins plays an important role in plasma membrane
bioactivity, and much can be learned from their diffusion characteristics. Here we present the …

The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …

Based on recent single-molecule imaging results in the living cell plasma membrane, we
propose a hierarchical architecture of three-tiered mesoscale (2–300nm) domains to …

Lipid microdomains are postulated to regulate many membrane-associated processes but
have remained highly controversial. Here we provide the first direct evidence that the …

Scanning ion conductance microscopy (SICM) is a versatile type of scanning probe
microscopy for studies in molecular biology and materials science. Recent advances in …

Increasing evidence supports the existence of lateral nanoscopic lipid domains in plasma
membranes, known as lipid rafts. These domains preferentially recruit membrane proteins …

The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic
nanodomains many of which are liquid entities surrounded by a second, slightly different …