Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

KM Hastie, H Li, D Bedinger, SL Schendel… - Science, 2021 - science.org
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

[HTML][HTML] Molecular basis of receptor binding and antibody neutralization of Omicron

Q Hong, W Han, J Li, S Xu, Y Wang, C Xu, Z Li, Y Wang… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …

Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies

Y Wang, C Liu, C Zhang, Y Wang, Q Hong, S Xu… - Nature …, 2022 - nature.com
Abstract The SARS-CoV-2 Delta variant is currently the dominant circulating strain in the
world. Uncovering the structural basis of the enhanced transmission and altered immune …

Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM

Y Wang, C Xu, Y Wang, Q Hong, C Zhang, Z Li… - Nature …, 2021 - nature.com
The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility
and resistance to neutralizing antibodies has created new challenges for the control of the …

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

B Schepens, L van Schie, W Nerinckx… - Science Translational …, 2021 - science.org
Broadly neutralizing antibodies are an important treatment for individuals with coronavirus
disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 …

The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein

HM Dokainish, S Re, T Mori, C Kobayashi, J Jung… - Elife, 2022 - elifesciences.org
Spike (S) protein is the primary antigenic target for neutralization and vaccine development
for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It decorates the …

Spatially patterned neutralizing icosahedral DNA nanocage for efficient SARS-CoV-2 blocking

J Zhang, Y Xu, Y Huang, M Sun, S Liu… - Journal of the …, 2022 - ACS Publications
Broad-spectrum anti-SARS-CoV-2 strategies that can inhibit the infection of wild-type and
mutant strains would alleviate their threats to global public health. Here, we propose an …

Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment

NA Valdez-Cruz, E García-Hernández, C Espitia… - Microbial cell …, 2021 - Springer
SARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which
spread rapidly, infecting more than 134 million people, and killing almost 2.9 million thus far …