Abstract Classical macrolides containing 14-or 15-membered aglycone lactone rings are
basic and widely used antibacterial agents in clinical therapy. Macrolides exert antibacterial …

Structure-Activity Relationships and Mechanism of Action of Macrolides Derived from
Erythromycin as Antibacterial Agents Page 1 Send Orders for Reprints to reprints@benthamscience.net …

Staphylococcus aureus (S. aureus), recognized as one of the deadliest pathogens
responsible for nosocomial and community acquired infections, is highly contagious and …

Ketolides are the fourth generation semisynthetic macrolides derived from erythromycin A,
designed to address the limitations of currently available drug treatments including …

We report a series of new 9-oxime ether non-ketolides, including 3-hydroxyl, 3-O-acyl and 3-
O-alkyl clarithromycin derivatives, and thiophene-containing ketolides 1b–1d. Unlike …

A novel series of 3-O-arylalkylcarbamoyl-3-O-descladinosyl-9-O-(2-chlorobenzyl) oxime
clarithromycin derivatives, were designed, synthesized and evaluated for their in vitro …

Bacterial resistance to the existing drugs requires constant development of new antibiotics.
Developing compounds active against gram-negative bacteria thereby is one of the more …

Constitutively erythromycin-resistant apathogens are more difficult to address than inducibly
resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime …

A series of quinoylalkyl side chains was designed and synthesized, followed by introduction
into ketolides by coupling with building block 6 or 32. The corresponding targets 7a–n, 33b …

Oxime acylides have different SAR and binding modes from 9-oxime ketolides. An
aminopyridyl or carbamoylpyridyl group anchored at the end of the 9-oxime 2-propargyl …