Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

The gut–brain axis and its relation to Parkinson's disease: a review

EM Klann, U Dissanayake, A Gurrala… - Frontiers in aging …, 2022 - frontiersin.org
Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …

Microbiota-brain-gut axis and neurodegenerative diseases

EMM Quigley - Current neurology and neuroscience reports, 2017 - Springer
Abstract Purpose of Review The purposes of this review were as follows: first, to provide an
overview of the gut microbiota and its interactions with the gut and the central nervous …

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

M Barichella, M Severgnini, R Cilia… - Movement …, 2019 - Wiley Online Library
Background Although several studies have suggested that abnormalities in gut microbiota
may play a critical role in the pathogenesis of PD, data are still extremely heterogeneous …

Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

S Westfall, N Lomis, I Kahouli, SY Dia, SP Singh… - Cellular and molecular …, 2017 - Springer
The gut microbiota is essential to health and has recently become a target for live bacterial
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

MC Houser, MG Tansey - NPJ Parkinson's disease, 2017 - nature.com
The state of the intestinal environment can have profound effects on the activity of the central
nervous system through the physiological contributions of the microbiota, regulation of …

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's Disease

MF Sun, YQ Shen - Ageing research reviews, 2018 - Elsevier
Gut microbial dysbiosis and alteration of microbial metabolites in Parkinson's disease (PD)
have been increasingly reported. Dysbiosis in the composition and abundance of gut …

Recent developments in understanding the role of the gut microbiota in brain health and disease

E Sherwin, TG Dinan, JF Cryan - … of the New York Academy of …, 2018 - Wiley Online Library
There is a growing appreciation of the role of the gut microbiota in all aspects of health and
disease, including brain health. Indeed, roles for the bacterial commensals in various …

Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

LJ Spielman, DL Gibson, A Klegeris - Neurochemistry international, 2018 - Elsevier
The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …

[HTML][HTML] Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market

L Diez-Gutiérrez, L San Vicente, LJR Barrón… - Journal of Functional …, 2020 - Elsevier
Probiotics have attracted growing interest in recent decades due to their multiple health
benefits. The synergistic relationship between probiotics and prebiotics can enhance the …