Reactive oxygen species‐(ROS‐) induced lipid peroxidation plays a critical role in cell death
including apoptosis, autophagy, and ferroptosis. This fundamental and conserved …

Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Background Ferroptosis is a recently identified iron-dependent form of cell death as a result
of increased reactive oxygen species (ROS) and lipid peroxidation. In this study, we …

This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

It is well known that regular exercise can benefit health by enhancing antioxidant defenses
in the body. However, unaccustomed and/or exhaustive exercise can generate excessive …

As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

The existence of free radicals in living cells was first reported in 1954 and this important
finding helped launch the field of free radical biology. However, the discovery that muscular …

The pivotal observation that muscular exercise is associated with oxidative stress in humans
was first reported over 45 years ago. Soon after this landmark finding, it was discovered that …

Reactive oxygen species (ROS) are generated in skeletal muscle both during the rest and
contractile activity. Myogenic cells are equipped with antioxidant enzymes, like superoxide …

The sites and rates of mitochondrial production of superoxide and H 2 O 2 in vivo are not yet
defined. At least 10 different mitochondrial sites can generate these species. Each site has a …