Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …

Aging has been associated with damage accumulation in the genome and with increased
cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources …

Base excision repair is the system used from bacteria to man to remove the tens of
thousands of endogenous DNA damages produced daily in each human cell. Base excision …

Base excision repair (BER) proteins act upon a significantly broad spectrum of DNA lesions
that result from endogenous and exogenous sources. Multiple sub-pathways of BER (short …

A large variety of DNA lesions induced by environmental agents or arising as an outcome of
cellular metabolism are counteracted by a complex network of proteins that belong to the …

Base excision repair (BER) is the major pathway responsible for averting the mutagenic and
cytotoxic effects of spontaneous hydrolytic, oxidative, and non-enzymatic alkylation DNA …

Mutations are a critical driver of cancer initiation. While extensive studies have focused on
exposure-induced mutations, few studies have explored the importance of tissue physiology …

Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of
the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination …

We have detected DNA polymerase beta (Pol β), known as a key nuclear base excision
repair (BER) protein, in mitochondrial protein extracts derived from mammalian tissue and …