Advanced hepatocellular carcinoma (HCC) is a serious therapeutic challenge and targeted
therapies only provide a modest benefit in terms of overall survival. Novel approaches are …

Toxoplasma gondii, an apicomplexan parasite, is a pathogenic protozoan that can infect the
central nervous system. In pregnant women, infection can result in congenital problems of …

We performed massive single-cell sequencing in the aging mouse colonic epithelium and
immune cells. We identified novel compartment-specific markers as well as dramatic aging …

Hepatocellular carcinoma (HCC) remains a serious medical therapeutic challenge as
conventional curative avenues such as surgery and chemotherapy only benefit for few …

Toxoplasma gondii is an obligate intracellular parasite that can infect a broad range of
warmblooded animals. In humans, it can cause serious disease in immune-compromised …

Bispecific antibodies (BsAbs) or fusion proteins (BsAbFPs) present a promising strategy for
cancer immunotherapy. Numerous BsAbs targeting coinhibitory and costimulatory pathways …

Abstract CD40/CD40L interactions play a critical role in immunity and autoimmunity. In this
study, we sought to understand the requirement for CD40 signaling in the programmed cell …

Background: CD40 is an important immune costimulatory molecule that has recently been
found to be associated with chronic hepatitis B. This study aims to explore the association …

Одна из особенностей современных медицинских технологий заключается в
стремлении к экономически оправданным, эффективным, точным и наименее …

The work presented in this thesis aimed at the development of antibody immunoconjugates
for the delivery in tumor cells of highly immunogenic T cell epitopes that mediate the antigen …