Helminth immunomodulation in autoimmune disease

TB Smallwood, PR Giacomin, A Loukas… - Frontiers in …, 2017 - frontiersin.org
Helminths have evolved to become experts at subverting immune surveillance. Through
potent and persistent immune tempering, helminths can remain undetected in human …

Global issues in allergy and immunology: parasitic infections and allergy

AA Cruz, PJ Cooper, CA Figueiredo… - Journal of Allergy and …, 2017 - Elsevier
Allergic diseases are on the increase globally in parallel with a decrease in parasitic
infection. The inverse association between parasitic infections and allergy at an ecological …

Mining nematode protein secretomes to explain lifestyle and host specificity

L Tritten, C Ballesteros, R Beech… - PLoS Neglected …, 2021 - journals.plos.org
Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals
and plants. Despite great differences in their life cycles, host preference and transmission …

The role of microbiota in the pathogenesis of lupus: Dose it impact lupus nephritis?

YR Saadat, M Hejazian, M Bastami, SMH Khatibi… - Pharmacological …, 2019 - Elsevier
Systemic lupus erythematosus (SLE) is a complex, inflammatory, and autoimmune disease
triggered by complicated interactions of different factors. A major contributor to morbidity and …

Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model

S Sun, H Li, Y Yuan, L Wang, W He, H Xie, S Gao… - Parasites & vectors, 2019 - Springer
Background Helminths immunomodulate the host immune system by secreting proteins to
create an inhibitory environment as a strategy for survival in the host. As a bystander effect …

Parasite-based interventions in systemic lupus erythematosus (SLE): a systematic review

AA Jafari, M Keikha, S Mirmoeeni, MT Rahimi… - Autoimmunity …, 2021 - Elsevier
Background The hygiene hypothesis proposed in 1989 expresses that allergic and
infectious diseases are inversely related. Accordingly, it has been demonstrated that …

Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse …

FE Lumb, J Crowe, J Doonan, CJ Suckling… - Molecular and …, 2019 - Elsevier
One of the most rapidly increasing human public health problems is obesity, whose
sequelae like type-2 diabetes, represent continuously worsening, life-long conditions. Over …

Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis

S Wan, X Sun, F Wu, Z Yu, L Wang, D Lin, Z Li… - Journal of …, 2018 - Springer
Background Angiostrongylus cantonensis, an important foodborne parasite, can induce
serious eosinophilic meningitis in non-permissive hosts, such as mouse and human …

Mini review: Structure and function of nematode phosphorylcholine-containing glycoconjugates

G Buitrago, J Duncombe-Moore, MM Harnett… - Frontiers in Tropical …, 2021 - frontiersin.org
An unusual aspect of the biology of nematodes is the covalent attachment of
phosphorylcholine (PC) to carbohydrate in glycoconjugates. Investigation of the structure of …

Recombinant proteins of helminths with immunoregulatory properties and their possible therapeutic use

LN Santos, LGC Pacheco, CS Pinheiro… - Acta tropica, 2017 - Elsevier
The inverse relationship between helminth infections and the development of immune-
mediated diseases is a cornerstone of the hygiene hypothesis and studies were carried out …