Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops
this disease. Although previously tobacco‐derived carcinogens and enzyme polymorphisms …

Lung cancer is the leading cause of cancer-related mortality. While the majority of lung
cancers are associated with tobacco smoke, approximately 10–15% of US lung cancers …

Purpose Epidermal growth factor receptor (EGFR) mutations have been associated with
tumor response to treatment with single-agent EGFR inhibitors in patients with relapsed non …

Purpose: KRAS mutations are found in∼ 25% of lung adenocarcinomas in Western
countries and, as a group, have been strongly associated with cigarette smoking. These …

The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …

The proto-oncogene RAS, coding for a 21 kDa protein (p21), is mutated in 20% of lung
cancer. However, the literature remains controversial on its prognostic significance for …

I" Page 1 JOURNAL OF THE CH EM ICAL SOCIETY Chemical Communications Number 1
1990 One-pot Preparation of Derivatives of the Unknown 1,9-Diazaphenalene Ring by a …

Study objectives To provide a systematic overview of the literature investigating patient and
tumor factors that are predictive of survival for patients with non-small cell lung cancer …

Chronic obstructive pulmonary disease (COPD) and lung cancer comprise the leading
causes of lung disease-related mortality worldwide. Exposure to tobacco smoke is a mutual …

Lung cancer is becoming increasingly common in women and in the United States accounts
for more female cancer deaths annually than breast cancer. Many epidemiological studies …