A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …

The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …

Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as
the pathologic hallmark of several neurodegenerative diseases including Alzheimer's …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common
cause of dementia among the elderly population. The good correlation of the density and …

Small animal imaging has been recognized as an important tool in preclinical research.
Nevertheless, the results of non-invasive imaging are often disappointing owing to choice of …

Protein aggregation has been widely implicated in neurodegenerative diseases such as
Alzheimer's disease, frontotemporal dementia, Parkinson's disease, and Huntington …

Background Dysfunction of the cholinergic system and increased oxidative stress have a
crucial role in cognitive disorders including Alzheimer's disease (AD). Here, we have …

The formation of beta amyloid (Aβ) plaques in specific brain regions is one of the early
pathological hallmarks of Alzheimer's disease (AD). To enable the early detection of AD and …

A series of 22 donepezil analogues were synthesized through alkylation/benzylation and
compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be …

To develop novel CNS penetrant HDAC inhibitors, a new series of HDAC inhibitors having
benzoheterocycle were designed, synthesized, and biologically evaluated. Among the …