Identifying common transcriptome signatures of cancer by interpreting deep learning models

A Jha, M Quesnel-Vallières, D Wang… - Genome Biology, 2022 - Springer
Background Cancer is a set of diseases characterized by unchecked cell proliferation and
invasion of surrounding tissues. The many genes that have been genetically associated with …

Cancer stem cells are prevalent in the basal-like 2 and mesenchymal triple-negative breast cancer subtypes in vitro

M Olsson, P Larsson, J Johansson, VR Sah… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with the most
unfavorable clinical outcomes, in part due to tumor heterogeneity, treatment resistance, and …

Transcriptome meta-analysis of triple-negative breast cancer response to neoadjuvant chemotherapy

W Zhang, E Li, L Wang, BD Lehmann, XS Chen - Cancers, 2023 - mdpi.com
Simple Summary This study aimed to identify genes associated with neoadjuvant
chemotherapy (NAC) response and disease-free survival (DFS) of triple-negative breast …

A comprehensive genomic and transcriptomic dataset of triple-negative breast cancers

Q Chen, Y Liu, Y Gao, R Zhang, W Hou, Z Cao… - Scientific Data, 2022 - nature.com
Molecular subtyping of triple-negative breast cancer (TNBC) is essential for understanding
the mechanisms and discovering actionable targets of this highly heterogeneous type of …

Characteristics of recurrence, predictors for relapse and prognosis of rapid relapse triple-negative breast cancer

SL Cai, JJ Liu, YX Liu, SH Yu, X Liu, XQ Lin… - Frontiers in …, 2023 - frontiersin.org
Background Triple-negative breast cancer (TNBC) patients who recur at different times are
associated with distinct biological characteristics and prognoses. Research on rapid-relapse …

Immune-related gene signatures to predict the effectiveness of chemoimmunotherapy in triple-negative breast cancer using exploratory subgroup discovery

O Kholod, WI Basket, JB Mitchem, JT Kaifi, RD Hammer… - Cancers, 2022 - mdpi.com
Simple Summary Chemoimmunotherapy combinations have transformed the treatment
landscape for patients with triple-negative breast cancer (TNBC). However, the discovery of …

A new prognostic model including immune biomarkers, genomic proliferation tumor markers (AURKA and MYBL2) and clinical-pathological features optimizes …

E García-Torralba, E Navarro Manzano… - Frontiers in …, 2023 - frontiersin.org
Background Up to 30% of breast cancer (BC) patients treated with neoadjuvant
chemotherapy (NCT) will relapse. Our objective was to analyze the predictive capacity of …

TROPION-Breast03: a randomized phase III global trial of datopotamab deruxtecan±durvalumab in patients with triple-negative breast cancer and residual invasive …

A Bardia, L Pusztai, K Albain… - Therapeutic …, 2024 - journals.sagepub.com
Background: Despite advances in the treatment of early triple-negative breast cancer
(TNBC), patients with residual invasive disease after neoadjuvant therapy have a high risk of …

Low Hospital Volume Is Associated with Higher All-Cause Mortality in Black Women with Triple Negative Breast Cancer

S Obeng-Gyasi, D Handley, MI Elsaid… - Journal of Racial and …, 2023 - Springer
Introduction This study examines the association between hospital volume and all-cause
mortality in Black women with triple negative breast cancer (TNBC) who received surgery …

Radiomics-based signature of breast cancer on preoperative contrast-enhanced MRI to predict axillary metastasis

D Chen, X Liu, C Hu, R Hao, O Wang, Y Xiao - Future Oncology, 2022 - Taylor & Francis
Aim: This study aimed to predict axillary metastasis using radiology features in dynamic
contrast-enhanced MRI. Methods: This study included 243 breast lesions confirmed as …