Allosteric communication between two ligand-binding sites in a protein is a central aspect of
biological regulation that remains mechanistically unclear. Here we show that perturbations …

Predicting the binding affinity between protein monomers is of paramount importance for the
understanding of thermodynamical and structural factors that guide the formation of a …

Proteins can be destabilized by a number of environmental factors such as temperature, pH,
and mutation. The ability to subsequently restore function under these conditions by adding …