SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …

The cardioprotective effects of SGLT2 (sodium-glucose cotransporter 2) inhibitors may be
related to their ability to induce a fasting-like paradigm, which triggers the activation of …

Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

As a result of the association of a common polymorphism (rs2231142, Q141K) in the ATP-
binding cassette G2 (ABCG2) transporter with serum urate concentration in a genome-wide …

Autophagy is a lysosome-dependent intracellular degradative pathway, which mediates the
cellular adaptation to nutrient and oxygen depletion as well as to oxidative and endoplasmic …

Objectives Acute gout is an inflammatory response to MSU crystals. In our previous
research, Sirt1 was shown to have an effect in preventing acute gouty inflammation. In the …

Molecular docking and activity evaluation screened the dipeptide module GP with low
xanthine oxidase (XOD) inhibitory activity and modules KE and KN with high activity, and …

Hyperuricemia (HUA) is considered a potent risk factor for the development of gout, renal
failure, and cardiovascular disease. The current project was designed to use stevia (Stevia …

The endothelium plays a fundamental role in the biological processes that ensure
physiological vessel integrity, synthesizing numerous substances that are capable of …