Skin is the largest organ in the body which plays different roles in maintaining hemostasis.
Although this tissue has a high healing potential, severe skin wounds cannot heal without …

Background Recent advances in mosquito eradication and antimalarial treatments have
reduced the malaria burden only modestly. An effective malaria vaccine remains a high …

Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a
simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its …

Biodegradable polymers are largely employed in the biomedical field, ranging from tissue
regeneration to drug/vaccine delivery. The biodegradable polymers are highly …

Current FDA‐approved influenza vaccines are limited by variable year to year efficacy, low
immunogenicity, and poor stability outside of cold‐chain storage. Polymeric microparticles …

Recently, there has been increasing interest in the activation of mast cells to promote
vaccine efficacy. Several mast cell activating (MCA) compounds have been reported such as …

Background Malaria has high morbidity and mortality rates in some parts of tropical and
subtropical countries. Besides respiratory and metabolic function, lung plays a role in …

Over the past two centuries, most pandemics have been caused by zoonotic RNA viruses
with high mutation, infection, and transmission rates. Due to the importance of …

A key element in ensuring successful immunization is the efficient delivery of vaccines.
However, poor immunogenicity and adverse inflammatory immunogenic reactions make the …

In this study, immunoinformatics strategies were used to design a subunit vaccine against
malaria from immunogenic regions of three Plasmodium falciparum surface antigens; liver …