Pathophysiology of the right ventricle and its pulmonary vascular interaction

AR Hemnes, DS Celermajer, M D'Alto… - European …, 2024 - publications.ersnet.org
The right ventricle and its stress response is perhaps the most important arbiter of survival in
patients with pulmonary hypertension of many causes. The physiology of the …

Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)

LM Forbes, N Bauer, A Bhadra… - Pulmonary …, 2025 - Wiley Online Library
Pulmonary vascular disease is not a single condition; rather it can accompany a variety of
pathologies that impact the pulmonary vasculature. Applying precision medicine strategies …

Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension

N Baxan, L Zhao, A Ashek, M Niglas, D Wang… - Scientific Reports, 2024 - nature.com
Deep phenotyping the right ventricle (RV) is essential for understanding the mechanisms of
adaptive and maladaptive RV responses to pulmonary hypertension (PH). In this study …

Sex-specific genetic determinants of right ventricular structure and function

L Harbaum, JK Hennigs, J Pott… - American Journal of …, 2025 - atsjournals.org
Rationale: Although sex differences in right heart phenotypes have been observed, the
molecular drivers remain unknown. Objectives: To provide biological insights into sex …

Proteomic Signatures of Right Ventricular Outcomes in Pulmonary Arterial Hypertension

H Pi, L Xia, O Boucherat, K Suresh… - Circulation: Heart …, 2024 - ahajournals.org
BACKGROUND: Pulmonary arterial hypertension (PAH) is a disease of progressive right
ventricular (RV) failure with high morbidity and mortality. Our goal is to investigate proteomic …

Prognostic Significance of Proteomics‐Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension

T Yokokawa, O Boucherat, S Martineau… - Journal of the …, 2024 - Am Heart Assoc
Background Pulmonary arterial hypertension (PAH) ultimately leads to right ventricular
failure and premature death. The identification of circulating biomarkers with prognostic …

Biomarkers of RV dysfunction in HFrEF identified by direct tissue proteomics: extracellular proteins fibromodulin and fibulin-5

M Běhounek, D Lipcseyová, O Vít, P Žáček… - Circulation: Heart …, 2024 - ahajournals.org
BACKGROUND: Right ventricular dysfunction (RVD) is common in patients with heart failure
with reduced ejection fraction, and it is associated with poor prognosis. However, no …

Mendelian Randomization in Pulmonary Arterial Hypertension: Unveiling Early Insights With Promise for Future Discoveries

S Provencher, BJ Arsenault… - Journal of the American …, 2024 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a complex condition characterized by the gradual
restructuring of the distal pulmonary arteries, culminating in right ventricular failure and …

Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs

F Kazmirczak, R Moon, NT Vogel… - American Journal of …, 2024 - atsjournals.org
Right ventricular failure (RVF) is the leading cause of morbidity and mortality in pulmonary
arterial hypertension (PAH), but we currently lack therapies that enhance right ventricular …

Decoding Sex Differences in Right Ventricular Function through BMPR1A

EN Tóth, J van Wezenbeek… - American Journal of …, 2025 - atsjournals.org
Sex differences in cardiovascular physiology have been reported consistently both in
healthy individuals as well as in diseases that affect the right ventricle, such as pulmonary …