Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

Efficient transcriptional programming promises to open new frontiers in regenerative
medicine. However, mechanisms by which programming factors transform cell fate are …

Netrins are a family of proteins that direct cell and axon migration during development.
Three secreted netrins (netrin-1,-3 and-4) have been identified in mammals, in addition to …

Respiration in mammals relies on the rhythmic firing of neurons in the phrenic motor column
(PMC), a motor neuron group that provides the sole source of diaphragm innervation …

A disintegrin and metalloprotease (ADAM) transmembrane proteins have metalloprotease,
integrin-binding, intracellular signaling and cell adhesion activities. In contrast to other …

Background In developing neurons, somal migration and initiation of axon outgrowth often
occur simultaneously and are regulated in part by similar classes of molecules. When …

Transcription factors establish the tremendous diversity of cell types in the nervous system
by regulating the expression of genes that give a cell its morphological and functional …

Coordinated limb rhythmic movements take place through organized signaling in local
spinal cord neuronal networks. The establishment of these circuitries during development is …

Netrin 1 (Ntn1) is a multifunctional guidance cue expressed in the ventricular zone and floor
plate of the embryonic neural tube. Although Ntn1 is best known for acting as an axon …