Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …

In the last years, proteomics has represented a valuable approach to elucidate key aspects
in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved …

Background Infections by viruses including severe acute respiratory syndrome coronavirus 2
could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate …

The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in
various biological processes, especially in regulating a wide range of signaling pathways …

Enhancing host resistance to infectious disease has received increasing attention in recent
years as a major goal of farm animal breeding programs. Combining field data with genomic …

RNA helicases play critical roles in various biological processes, including serving as viral
RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 …

The innate immune system responds rapidly to protect against viral infections, but an
overactive response can cause harmful damage. To avoid this, the response is tightly …

Abstract IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in
defensing virus and promoting inflammatory responses. Although several kinds of …