Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias
PD Swaminathan, A Purohit, TJ Hund… - Circulation …, 2012 - Am Heart Assoc
Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …
suffering and sudden death, remains an unmet goal for biomedical researchers and …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …
Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation
N Hamdani, J Krysiak, MM Kreusser, S Neef… - Circulation …, 2013 - Am Heart Assoc
Rationale: Myocardial diastolic stiffness and cardiomyocyte passive force (Fpassive) depend
in part on titin isoform composition and phosphorylation. Ca2+/calmodulin-dependent …
in part on titin isoform composition and phosphorylation. Ca2+/calmodulin-dependent …
A detailed mathematical model of the human atrial cardiomyocyte: Integration of electrophysiology and cardiomechanics
Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …
Local control of β-adrenergic stimulation: effects on ventricular myocyte electrophysiology and Ca2+-transient
Local signaling domains and numerous interacting molecular pathways and substrates
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …
A heart for diversity: simulating variability in cardiac arrhythmia research
In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …
These include variability in conditions and environment, and genotypic and molecular …
[HTML][HTML] Molecular pathogenesis of long QT syndrome type 2
JL Smith, CL Anderson, DE Burgess, CS Elayi… - Journal of …, 2016 - Elsevier
The molecular mechanisms underlying congenital long QT syndrome (LQTS) are now
beginning to be understood. New insights into the etiology and therapeutic strategies are …
beginning to be understood. New insights into the etiology and therapeutic strategies are …
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII
Key points Intracellular [Na+]([Na+] i) is elevated in heart failure (HF) and causes
arrhythmogenic cellular [Ca2+] i loading. In HF, hyperactivity of Ca2+–calmodulin …
arrhythmogenic cellular [Ca2+] i loading. In HF, hyperactivity of Ca2+–calmodulin …
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel
therapeutic compounds. However, interspecies differences in the mechanisms regulating …
therapeutic compounds. However, interspecies differences in the mechanisms regulating …