Adipose tissue develops lipids, aberrant adipokines, chemokines, and pro-inflammatory
cytokines as a consequence of the low-grade systemic inflammation that characterizes …

Simple Summary The response rate to immune checkpoint inhibitor (ICI) monotherapy in
hepatocellular carcinoma (HCC) is as low as 20%; therefore, it is important to identify the …

Background: HCC is the leading cause of cancer in chronic liver disease. A growing body of
experimental mouse models supports the notion that gut-resident and liver-resident …

TP53 R249S mutation in hepatic organoids captures the predis... : Hepatology TP53 R249S
mutation in hepatic organoids captures the predisposing cancer risk : Hepatology AASLD …

MYC, a major oncogenic transcription factor, regulates target genes involved in various
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …

Background Nonalcoholic fatty liver disease affects about 24% of the world's population and
may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality
worldwide. The emergence of combination therapy, atezolizumab (anti-PDL1, immune …

The liver is essential for metabolic homeostasis. The onset of liver cancer is often
accompanied by dysregulated liver function, leading to metabolic rearrangements …

Dysregulation of the aldehyde dehydrogenase (ALDH) family has been implicated in various
pathological conditions, including cancer. However, a systematic evaluation of ALDH …

Uveal melanoma (UVM) is the most common primary tumor in adult human eyes.
Costimulatory molecules (CMs) are important in maintaining T cell biological functions and …