State-of-the-art strategies for targeting the DNA damage response in cancer
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …
damage response (DDR) and/or increased replication stress. These alterations promote the …
Mesothelioma: Scientific clues for prevention, diagnosis, and therapy
M Carbone, PS Adusumilli… - CA: a cancer journal …, 2019 - Wiley Online Library
Mesothelioma affects mostly older individuals who have been occupationally exposed to
asbestos. The global mesothelioma incidence and mortality rates are unknown, because …
asbestos. The global mesothelioma incidence and mortality rates are unknown, because …
Integrative analysis identifies four molecular and clinical subsets in uveal melanoma
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …
molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis …
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer
Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
NA Snyder, GM Silva - Journal of Biological Chemistry, 2021 - ASBMB
Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …
Prevalence of homologous recombination–related gene mutations across multiple cancer types
Purpose The prevalence of homologous recombination DNA damage repair (HR-DDR)
deficiencies among all tumor lineages is not well characterized. Therapy directed toward …
deficiencies among all tumor lineages is not well characterized. Therapy directed toward …
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
Abstract BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that
modulates environmental carcinogenesis,,. All carriers of inherited heterozygous germline …
modulates environmental carcinogenesis,,. All carriers of inherited heterozygous germline …
Uveal melanoma: Towards a molecular understanding
KN Smit, MJ Jager, A de Klein, E Kiliҫ - Progress in retinal and eye …, 2020 - Elsevier
Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye.
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …
Novel insights into mesothelioma biology and implications for therapy
Malignant mesothelioma is a universally lethal cancer that is increasing in incidence
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide
S Walpole, AL Pritchard, CM Cebulla… - JNCI: Journal of the …, 2018 - academic.oup.com
Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …