Detecting liquid remnants of solid tumors: circulating tumor DNA minimal residual disease

EJ Moding, BY Nabet, AA Alizadeh, M Diehn - Cancer discovery, 2021 - AACR
Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual
disease (MRD) following treatment for solid tumors predicts relapse. These results suggest …

[HTML][HTML] ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

A Dasari, VK Morris, CJ Allegra, C Atreya… - Nature reviews Clinical …, 2020 - nature.com
An increasing number of studies are describing potential uses of circulating tumour DNA
(ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area …

[HTML][HTML] Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer

D Kotani, E Oki, Y Nakamura, H Yukami, S Mishima… - Nature medicine, 2023 - nature.com
Despite standard-of-care treatment, more than 30% of patients with resectable colorectal
cancer (CRC) relapse. Circulating tumor DNA (ctDNA) analysis may enable postsurgical risk …

Practical recommendations for using ctDNA in clinical decision making

SA Cohen, MC Liu, A Aleshin - Nature, 2023 - nature.com
The continuous improvement in cancer care over the past decade has led to a gradual
decrease in cancer-related deaths. This is largely attributed to improved treatment and …

Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer

WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

[HTML][HTML] Bridging biological cfDNA features and machine learning approaches

T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

A Zviran, RC Schulman, M Shah, STK Hill… - Nature medicine, 2020 - nature.com
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-
free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the …

[HTML][HTML] Circulating tumor DNA and minimal residual disease (MRD) in solid tumors: current horizons and future perspectives

Y Peng, W Mei, K Ma, C Zeng - Frontiers in oncology, 2021 - frontiersin.org
Circulating tumor DNA (ctDNA) is cell-free DNA (cfDNA) fragment in the bloodstream that
originates from malignant tumors or circulating tumor cells. Recently, ctDNA has emerged as …

[HTML][HTML] Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer

N Tarazona, F Gimeno-Valiente, V Gambardella… - Annals of …, 2019 - Elsevier
Background A high percentage of patients diagnosed with localized colon cancer (CC) will
relapse after curative treatment. Although pathological staging currently guides our …

[HTML][HTML] Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer

G Chen, J Peng, Q Xiao, HX Wu, X Wu, F Wang… - Journal of hematology & …, 2021 - Springer
Background Precise methods for postoperative risk stratification to guide the administration
of adjuvant chemotherapy (ACT) in localized colorectal cancer (CRC) are still lacking. Here …