The biphasic function of microglia in ischemic stroke

Y Ma, J Wang, Y Wang, GY Yang - Progress in neurobiology, 2017 - Elsevier
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Astrocyte roles in traumatic brain injury

JE Burda, AM Bernstein, MV Sofroniew - Experimental neurology, 2016 - Elsevier
Astrocytes sense changes in neural activity and extracellular space composition. In
response, they exert homeostatic mechanisms critical for maintaining neural circuit function …

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

Z Liu, M Chopp - Progress in neurobiology, 2016 - Elsevier
Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

L Hösli, N Binini, KD Ferrari, L Thieren, ZJ Looser… - Cell reports, 2022 - cell.com
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

Synaptopathies: synaptic dysfunction in neurological disorders–A review from students to students

K Lepeta, MV Lourenco, BC Schweitzer… - Journal of …, 2016 - Wiley Online Library
Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Heterogeneity of astrocytic form and function

NA Oberheim, SA Goldman, M Nedergaard - Astrocytes: Methods and …, 2012 - Springer
Astrocytes participate in all essential CNS functions, including blood flow regulation, energy
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …

ATP mediates rapid microglial response to local brain injury in vivo

D Davalos, J Grutzendler, G Yang, JV Kim, Y Zuo… - Nature …, 2005 - nature.com
Parenchymal microglia are the principal immune cells of the brain. Time-lapse two-photon
imaging of GFP-labeled microglia demonstrates that the fine termini of microglial processes …

Astroglial networks: a step further in neuroglial and gliovascular interactions

C Giaume, A Koulakoff, L Roux, D Holcman… - Nature Reviews …, 2010 - nature.com
Dynamic aspects of interactions between astrocytes, neurons and the vasculature have
recently been in the neuroscience spotlight. It has emerged that not only neurons but also …

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Gliomas and the vascular fragility of the blood brain barrier

LG Dubois, L Campanati, C Righy… - Frontiers in cellular …, 2014 - frontiersin.org
Astrocytes, members of the glial family, interact through the exchange of soluble factors or by
directly contacting neurons and other brain cells, such as microglia and endothelial cells …