The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …

Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …

Abstract Three-dimensional (3D) cell culture technologies, such as organoids, are
physiologically relevant models for basic and clinical applications. Automated microfluidics …

Introduction: Targeted therapies in cancer aim to inhibit specific molecular targets
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …

Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Epigenetic modulation of gene activity occurs in response to non-genetic factors such as
body weight status, physical activity, dietary factors, and environmental toxins. In addition …

Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

Preclinical models of cancer are essential for a basic understanding of cancer biology and
its translation into efficient treatment options for affected patients. Cancer cell lines and …

Human IgG is the main antibody class used in antibody therapies because of its efficacy and
longer half-life, which are completely or partly due to FcγR-mediated functions of the …

Nanoparticles (NPs) have become an important tool in many industries including healthcare.
The use of NPs for drug delivery and imaging has introduced exciting opportunities for the …