RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms
of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is …

Background & Aims Transforming growth factor-b (TGFb) plays pleiotropic roles in
pancreatic cancer, including promoting metastasis, attenuating CD8 T-cell activation, and …

Completion of early stages of tumorigenesis relies on the dynamic interplay between the
initiating oncogenic event and the cellular context. Here, we review recent findings …

Background Excess adiposity is considered causally related to pancreatic cancer. While
most knowledge on the topic comes from studies on general and visceral adiposity, the role …

Metabolic reprogramming is a feature of cancers for which recent research has been
particularly active, providing numerous insights into the mechanisms involved. It occurs …

Pancreatic cancer (PC) is the deadliest neoplastic epithelial malignancies and is projected
to be the second leading cause of cancer-related mortality by 2024. Five years overall …

Acinar-to-ductal metaplasia (ADM) is a recently recognized, yet less well-studied, precursor
lesion of pancreatic ductal adenocarcinoma (PDAC) developed in the setting of chronic …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, and it is
currently the third most common cause of cancer death in the USA Progress in the fight …

Acinar cell dedifferentiation is one of the most notable features of acute and chronic
pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In …