There is now compelling evidence that the excitatory amino acid neurotransmitter glutamate
plays a pivotal role in drug addiction and alcoholism. As a result, there has been increasing …

Storage and processing of information at the synaptic level is enabled by the ability of
synapses to persistently alter their efficacy. This phenomenon, known as synaptic plasticity …

DNA methylation is a covalent chemical modification of DNA catalyzed by DNA
methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing …

Gq-coupled, M1 muscarinic acetylcholine receptors (mAChRs) facilitate hippocampal
learning, memory, and synaptic plasticity. M1 mAChRs induce long-term synaptic …

Although metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5 are often found
to have similar functions, there is considerable evidence that the two receptors also serve …

An increasing amount of evidence suggests that the family of nuclear factor κB (NF-κB)
transcription factors plays an important role in synaptic plasticity and long-term memory …

Rationale Antagonists at the metabotropic glutamate 5 (mGlu5) receptor produce robust
anxiolytic effects in a number of rat tests. However, there is evidence that mGlu5 receptor …

Metabotropic glutamate receptor 5 (mGluR5), a subtype in the group I mGluRs, couples to
phospholipase C through Gq protein. Stimulation of mGluR5 leads to the release of calcium …

Glutamate plays a pivotal role in regulating drug self-administration and drug-seeking
behavior, and the past decade has witnessed a substantial surge of interest in the role of …

The purpose of the present study was to compare anxiolytic activity of the metabotropic
glutamate receptor 1 (mGlu) antagonist, EMQMCM ((3-ethyl-2-methyl-quinolin-6-yl)-(4 …