The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Nature offers a wealth of opportunities to solve scientific and technological issues based on
its unique structures and function. The dynamic non‐covalent interaction is considered to be …

The tumor microenvironment encompasses a complex cellular network that includes cancer-
associated fibroblasts, inflammatory cells, neo-vessels, and an extracellular matrix enriched …

In this study, we review mechanoregulatory roles for perlecan in load-bearing connective
tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly of elastic …

As essential components of our connective tissues, elastic fibres give tissues such as major
blood vessels, skin and the lungs their elasticity. Their formation is complex and co …

Fibrillin-1 is an extracellular matrix protein that assembles into microfibrils which provide
critical functions in large blood vessels and other tissues. Mutations in the fibrillin-1 gene are …