Detecting structural progression in glaucoma with optical coherence tomography

AJ Tatham, FA Medeiros - Ophthalmology, 2017 - Elsevier
Optical coherence tomography (OCT) is increasingly used to obtain objective measurements
of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma …

Discovery and clinical translation of novel glaucoma biomarkers

G Beykin, AM Norcia, VJ Srinivasan, A Dubra… - Progress in Retinal and …, 2021 - Elsevier
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …

Bruch's membrane opening minimum rim width and retinal nerve fiber layer thickness in a normal white population: a multicenter study

BC Chauhan, VM Danthurebandara, GP Sharpe… - Ophthalmology, 2015 - Elsevier
Purpose Conventional optic disc margin-based neuroretinal rim measurements lack a solid
anatomic and geometrical basis. An optical coherence tomography (OCT) index, Bruch's …

[HTML][HTML] Retinal nerve fiber layer features identified by unsupervised machine learning on optical coherence tomography scans predict glaucoma progression

M Christopher, A Belghith, RN Weinreb… - … & visual science, 2018 - tvst.arvojournals.org
Purpose: To apply computational techniques to wide-angle swept-source optical coherence
tomography (SS-OCT) images to identify novel, glaucoma-related structural features and …

A deep learning algorithm to quantify neuroretinal rim loss from optic disc photographs

AC Thompson, AA Jammal, FA Medeiros - American journal of …, 2019 - Elsevier
Purpose To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal
damage on fundus photographs using the minimum rim width relative to Bruch membrane …

[HTML][HTML] Enhanced structure–function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement

VM Danthurebandara, GP Sharpe… - … & visual science, 2015 - tvst.arvojournals.org
Purpose.: To evaluate the structure–function relationship between disc margin–based rim
area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's …

The morphological difference between glaucoma and other optic neuropathies

C Burgoyne - Journal of Neuro-ophthalmology, 2015 - journals.lww.com
The clinical phenomenon of cupping has 2 principal pathophysiologic components in all
optic neuropathies: prelaminar thinning and laminar deformation. We define prelaminar …

Diagnostic accuracy of optical coherence tomography and scanning laser tomography for identifying glaucoma in myopic eyes

R Malik, AC Belliveau, GP Sharpe, LM Shuba… - Ophthalmology, 2016 - Elsevier
Purpose Ruling out glaucoma in myopic eyes often poses a diagnostic challenge because
of atypical optic disc morphology and visual field defects that can mimic glaucoma. We …

[HTML][HTML] Structural measurements for monitoring change in glaucoma: comparing retinal nerve fiber layer thickness with minimum rim width and area

SK Gardiner, PY Boey, H Yang… - … & visual science, 2015 - jov.arvojournals.org
Purpose: Minimum rim width (MRW) and area (MRA) have been introduced as anatomically
defensible measures of neuroretinal rim tissue observable using spectral-domain optical …

What rates of glaucoma progression are clinically significant?

LJ Saunders, FA Medeiros, RN Weinreb… - Expert review of …, 2016 - Taylor & Francis
Introduction: Clinically important rates of glaucoma progression (worsening) are ones that
put a patient at risk of future functional impairment or reduction of vision-related quality of life …