Acromegaly is associated with high morbidity and elevated mortality when not adequately
treated. Surgery is the first-line treatment for most patients as it is the only one that can lead …

Purpose Biochemical control is the main determinant of survival, clinical manifestations and
comorbidities in acromegaly. Transsphenoidal selective adenomectomy (TSA) is the initial …

Purpose The aim of this systematic review is to evaluate the long-term endocrine outcomes
and postoperative complications following endoscopic vs. microscopic transsphenoidal …

Purpose To evaluate which radiological classification, Knosp, revised-Knosp, or Hardy–
Wilson classification, is better for the prediction of surgical outcomes in the endoscopic …

Gonadal steroids modulate the effects of GH, with oestrogens attenuating and androgens
augmenting GH action. Whether these divergent effects influence the clinical manifestation …

BACKGROUND: Long-term remission rates from endoscopic transsphenoidal surgery for
acromegaly and their relationship to prognostic indicators of disease aggressiveness are not …

Background Transsphenoidal surgery (TSS) is the cornerstone of acromegaly treatment,
however there are no robust predictors of surgical outcome and remission can only be …

Background The pituitary adenoma causing acromegaly is typically resected through a
transsphenoidal approach and visualized with an operating microscope or endoscope. We …

Objectives: Growth hormone-secreting pituitary adenomas in adults can result in severe
craniofacial disfigurement and potentially fatal medical complications. Surgical resection …

Purpose Growth hormone-producing pituitary adenomas are divided into two clinically
relevant histologic subtypes, densely (DG-A) and sparsely (SG-A) granulated. Histologic …