Optical tweezers in studies of red blood cells

R Zhu, T Avsievich, A Popov, I Meglinski - Cells, 2020 - mdpi.com
Optical tweezers (OTs) are innovative instruments utilized for the manipulation of
microscopic biological objects of interest. Rapid improvements in precision and degree of …

Advances in mechanical biomarkers

M Eroles, F Rico - Journal of Molecular Recognition, 2023 - Wiley Online Library
Mechanical biomarkers distinguish health conditions through quantitative mechanical
measurements. The emergence and establishment of nanotechnology in the last decades …

Deformability-induced lift force in spiral microchannels for cell separation

E Guzniczak, O Otto, G Whyte, N Willoughby… - Lab on a Chip, 2020 - pubs.rsc.org
Cell sorting and isolation from a heterogeneous mixture is a crucial task in many aspects of
cell biology, biotechnology and medicine. Recently, there has been an interest in methods …

High-throughput adjustable deformability cytometry utilizing elasto-inertial focusing and virtual fluidic channel

Z Zhou, C Ni, Z Zhu, Y Chen, Z Ni, N Xiang - Lab on a Chip, 2023 - pubs.rsc.org
Cell mechanical properties provide a label-free marker for indicating cell states and disease
processes. Although microfluidic deformability cytometry has demonstrated great potential …

Microparticles with tunable, cell-like properties for quantitative acoustic mechanophenotyping

R Dubay, EM Darling, J Fiering - Microsystems & Nanoengineering, 2023 - nature.com
Mechanical properties of biological cells have been shown to correlate with their
biomolecular state and function, and therefore methods to measure these properties at scale …

[HTML][HTML] Statistics for real-time deformability cytometry: Clustering, dimensionality reduction, and significance testing

M Herbig, A Mietke, P Müller, O Otto - Biomicrofluidics, 2018 - pubs.aip.org
Real-time deformability (RT-DC) is a method for high-throughput mechanical and
morphological phenotyping of cells in suspension. While analysis rates exceeding 1000 …

Microfluidic label-free bioprocessing of human reticulocytes from erythroid culture

KK Zeming, Y Sato, L Yin, NJ Huang, LH Wong… - Lab on a Chip, 2020 - pubs.rsc.org
In vitro erythroid cultures from human hematopoietic stem cells produce immature red blood
cells (RBCs) called reticulocytes, which are important for RBCs production, and are widely …

Biomechanics of ex vivo-generated red blood cells investigated by optical tweezers and digital holographic microscopy

C Bernecker, MARBF Lima, CD Ciubotaru, P Schlenke… - Cells, 2021 - mdpi.com
Ex vivo-generated red blood cells are a promising resource for future safe blood products,
manufactured independently of voluntary blood donations. The physiological process of …

High-throughput single-cell mechanical phenotyping with real-time deformability cytometry

M Urbanska, P Rosendahl, M Kraeter, J Guck - Methods in cell biology, 2018 - Elsevier
Mechanical properties of cells can serve as a label-free marker of cell state and function and
their alterations have been implicated in processes such as cancer metastasis, leukocyte …

Cardiomyocyte mechanodynamics under conditions of actin remodelling

RH Pires, N Shree, E Manu… - … Transactions of the …, 2019 - royalsocietypublishing.org
The mechanical performance of cardiomyocytes (CMs) is an important indicator of their
maturation state and of primary importance for the development of therapies based on …