Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The unique properties of self-healing materials hold great potential in the field of biomedical
engineering. Although previous studies have focused on the design and synthesis of self …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Elastin is expressed in most tissues that require elastic recoil. The protein first appeared
coincident with the closed circulatory system, and was critical for the evolutionary success of …

Background: Marfan syndrome (MFS) is an autosomal dominant disorder of the connective
tissue caused by mutations in the FBN1 (fibrillin-1) gene encoding a large glycoprotein in …

Objective: microRNAs are master regulators of gene expression with essential roles in
virtually all biological processes. miR-217 has been associated with aging and cellular …

Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …

Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …