The lowdown on breakdown: Open questions in plant proteolysis

NA Eckardt, T Avin-Wittenberg, DC Bassham… - The Plant …, 2024 - academic.oup.com
Proteolysis, including post-translational proteolytic processing as well as protein
degradation and amino acid recycling, is an essential component of the growth and …

Chloroplast proteostasis: A story of birth, life, and death

LL Gao, ZH Hong, Y Wang, GZ Wu - Plant Communications, 2023 - cell.com
Protein homeostasis (proteostasis) is a dynamic balance of protein synthesis and
degradation. Because of the endosymbiotic origin of chloroplasts and the massive transfer of …

The Arabidopsis PeptideAtlas: harnessing worldwide proteomics data to create a comprehensive community proteomics resource

KJ Van Wijk, T Leppert, Q Sun, SS Boguraev… - The Plant …, 2021 - academic.oup.com
We developed a resource, the Arabidopsis PeptideAtlas (www. peptideatlas.
org/builds/arabidopsis/), to solve central questions about the Arabidopsis thaliana proteome …

Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: a comparative analysis

I Bouchnak, KJ van Wijk - Journal of Biological Chemistry, 2021 - ASBMB
ATPases Associated with diverse cellular Activities (AAA+) are a superfamily of proteins that
typically assemble into hexameric rings. These proteins contain AAA+ domains with two …

Mutant noxy8 exposes functional specificities between the chloroplast chaperones CLPC1 and CLPC2 in the response to organelle stress and plant defence

B López, Y Izquierdo, T Cascón… - Plant, cell & …, 2024 - Wiley Online Library
Chloroplast function is essential for growth, development, and plant adaptation to stress.
Organelle stress and plant defence responses were examined here using noxy8 …

N-degron pathways in plastids

I Bouchnak, KJ van Wijk - Trends in plant science, 2019 - cell.com
Protein amino (N) termini are major determinants of protein stability in the cytosol of
eukaryotes and prokaryotes, conceptualized in the N-end rule pathway, lately referred to as …

The chloroplast protease system degrades stromal DUF760-1 and DUF760-2 domain-containing proteins at different rates

B Yuan, KJ van Wijk - Plant Physiology, 2024 - academic.oup.com
The chloroplast chaperone CLPC1 aids to select, unfold, and deliver hundreds of proteins to
the CLP protease for degradation. Through in vivo CLPC1, trapping we previously identified …

A proteostasis network safeguards the chloroplast proteome

E Llamas, P Pulido - Essays in Biochemistry, 2022 - portlandpress.com
Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of
proteins that localize in plant chloroplasts, the indispensable organelles that perform …

Acyldepsipeptide analogues: a future generation antibiotics for tuberculosis treatment

SZZ Cobongela, MM Makatini, PS Mdluli, NRS Sibuyi - Pharmaceutics, 2022 - mdpi.com
Acyldepsipeptides (ADEPs) are a new class of emerging antimicrobial peptides (AMPs),
which are currently explored for treatment of pathogenic infections, including tuberculosis …

Uvr motifs regulate the chloroplast Clp chaperone–protease system

MY Annis, CM Ravenburg, KJ van Wijk - Trends in Plant Science, 2024 - cell.com
Chloroplast proteostasis relies on diverse proteases, including the essential Clp chaperone–
protease system. Two chloroplast ClpC AAA+ chaperones and the plant-specific adaptor …