In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Selective autophagy recycles damaged organelles and clears intracellular pathogens to
prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during …

A fundamental assumption in statistical physics is that generic closed quantum many-body
systems thermalize under their own dynamics. Recently, the emergence of many-body …

Biological cells are highly organized, with numerous subcellular compartments.
Phosphorylation has been hypothesized as a means to control the assembly/disassembly of …

The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate
more than half of the human kinome. However, both the mechanism by which these …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy
balance by sensing and responding to increases in AMP/ADP concentration relative to ATP …

The presence of DNA in the cytoplasm is a danger signal that triggers immune and
inflammatory responses. Cytosolic DNA binds to and activates cyclic GMP-AMP (cGAMP) …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …