Mitochondria regulate hepatic lipid metabolism and oxidative stress. Ultrastructural
mitochondrial lesions, altered mitochondrial dynamics, decreased activity of respiratory …

Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …

The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner
mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

Obesity results when energy intake exceeds energy expenditure. Naturally occurring genetic
mutations, as well as ablative lesions, have shown that the brain regulates both aspects of …

Uncoupling protein 2 (UCP2) is involved in various physiological and pathological
processes such as insulin secretion, stem cell differentiation, cancer, and aging. However …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do
not mediate adaptive thermogenesis, but they may be significantly thermogenic under …

Abstract β cells sense glucose through its metabolism and the resulting increase in ATP,
which subsequently stimulates insulin secretion. Uncoupling protein-2 (UCP2) mediates …