Background Irisin is a newly discovered hormone that is proposed to be a promising
therapeutic target in obesity and type 2 diabetes. It has received remarkable attention …

Soon after the discovery of the muscle‐derived factor irisin, a great controversy arose in the
literature regarding certain inconsistencies in the regulation of the fibronectin type III domain …

Objective We determined detailed time-course changes in the irisin response to acute
exercise using different exercise modes. Methods In experiment 1, seven healthy males …

FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and
diabetes because it is induced in muscle by exercise, increasing energy expenditure …

Irisin, a myokine released during exercise, promotes browning of subcutaneous adipose
tissue and regulates energy homeostasis. Although exercise constantly reduces blood …

Context: Irisin is a recently identified myokine affecting metabolic and glucose homeostasis.
However, the role of irisin in obesity and its metabolic consequences are controversial, and …

Objective Muscle and fat are now recognized as metabolism-regulating endocrine organs.
However, muscle and adipocyte-derived novel cytokines such as irisin and omentin-1 …

Background and Purpose Skeletal muscle is the predominant site for glucose disposal and
fatty acid consumption. Emerging evidence indicates that the crosstalk between adipose …

Almost four years after the discovery of the anabolic action of irisin on bone in mice, ample
clinical evidence is emerging in support of its additional physiological relevance in human …

Context Irisin, a novel exercise-induced myokine, has been suggested to regulate energy
metabolism. Objective We studied the relationship between circulating irisin and metabolic …