Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins
that provide protection for the chromosome terminus by blocking inappropriate …

Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-
Ten1). Recent data show that CST components are conserved and required for telomere …

Summary Budding yeast Cdc13, Stn1, and Ten1 form the CST complex to protect telomeres
from lethal DNA degradation. It remains unknown whether similar complexes are conserved …

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of
the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the …

Coats plus (CP) can be caused by mutations in the CTC1 component of CST, which
promotes polymerase α (polα)/primase-dependent fill-in throughout the genome and at …

Meiosis is essential for eukaryotic sexual reproduction, with two consecutive rounds of
nuclear divisions, allowing production of haploid gametes. Information regarding the meiotic …

The telosome/shelterin, a six-protein complex formed by TRF1, TRF2, RAP1, TIN2, POT1,
and TPP1, functions as the core of the telomere interactome, acting as the molecular …

In budding yeast, Cdc13, Stn1, and Ten1 form a heterotrimeric complex (CST) that is
essential for telomere protection and maintenance. Previous bioinformatics analysis …

Telomere overhangs are essential for telomere end protection and telomerase extension,
but how telomere overhangs are generated is unknown. Leading daughter strands …

Recent advances in our structural understanding of telomerase and telomere-associated
proteins have contributed significantly to elucidating the molecular mechanisms of telomere …