Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing
threat to global health. Both clonal spread and plasmid-mediated transmission contribute to …

Background The efficacy of ceftazidime-avibactam—a cephalosporin–β-lactamase inhibitor
combination with in vitro activity against Klebsiella pneumoniae carbapenemase–producing …

Urinary tract infections (UTIs) are among the most frequent infectious diseases affecting
humans, and represent an important public health problem with a substantial economic …

The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

With the advent of the antibiotic era, the overuse and inappropriate consumption and
application of antibiotics have driven the rapid emergence of multidrug-resistant pathogens …

Antimicrobial resistance (AMR), one among the most common priority areas identified by
both national and international agencies, is mushrooming as a silent pandemic. The …

Abstract OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly
reported in enterobacterial species. To date, six OXA-48-like variants have been identified …

The emergence of one of the most recently described carbapenemases, namely, the New
Delhi metallo‐lactamase (NDM‐1), constitutes a critical and growingly important medical …

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-
negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ …