Functional diversity of mammalian small heat shock proteins: a review

C Gu, X Fan, W Yu - Cells, 2023 - mdpi.com
The small heat shock proteins (sHSPs), whose molecular weight ranges from 12∼ 43 kDa,
are members of the heat shock protein (HSP) family that are widely found in all organisms …

Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Y Zou, H Shi, N Liu, H Wang, X Song… - Frontiers in …, 2023 - frontiersin.org
Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a
variety of cellular stress states. It is involved in regulating proteostasis and protecting cells …

The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease

J Meng, J Fang, Y Bao, H Chen, X Hu, Z Wang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Ferroptosis-driven loss of dopaminergic neurons plays a pivotal role in the
pathogenesis of Parkinson's disease (PD). In PD patients, Hspb1 is commonly observed at …

RNA‐Seq‐based discovery of genetic variants and allele‐specific expression of two layer lines and broiler chicken

MA Iqbal, F Hadlich, H Reyer, M Oster… - Evolutionary …, 2023 - Wiley Online Library
Recent advances in the selective breeding of broilers and layers have made poultry
production one of the fastest‐growing industries. In this study, a transcriptome variant calling …

Weighted single-step GWAS identifies genes influencing Fillet Color in Rainbow Trout

RO Ahmed, A Ali, R Al-Tobasei, T Leeds, B Kenney… - Genes, 2022 - mdpi.com
The visual appearance of the fish fillet is a significant determinant of consumers' purchase
decisions. Depending on the rainbow trout diet, a uniform bright white or reddish/pink fillet …

Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics …

J Liang, H Liu, G Lv, X Chen, Z Yang, K Hu… - Lipids in Health and …, 2025 - Springer
Clinical studies have suggested that tirzepatide may also possess hepatoprotective effects;
however, the molecular mechanisms underlying this association remain unclear. In our …

The heat shock protein 20 gene family in large yellow croaker (Larimichthys crocea): Identification, phylogenetic relationships, expression analyses

W Yan, X Liu, X Wang - Aquatic Toxicology, 2023 - Elsevier
Large yellow croaker (Larimichthys crocea) is an economically important fish in China, but
its aquaculture industry has been threatened by both biotic and abiotic stressors such as …

Human Plasma‐Derived Extracellular Vesicles Protect Against Cerebral Ischemia‐Reperfusion Injury via HSP27 Phosphorylation

Y Wang, H Yang, L Zhao, X Yin, S Ai, M Hu… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke (IS) has become a serious public health problem, with patients undergoing
endovascular treatment experiencing ischemia‐reperfusion (I/R) injury, which exacerbates …

Stress-granules, P-bodies, and cell aging: A bioinformatics study

YI Mokin, NS Ilyinsky, SV Nesterov, EY Smirnov… - Biochemical and …, 2024 - Elsevier
At the molecular level, aging is often accompanied by dysfunction of stress-induced
membrane-less organelles (MLOs) and changes in their physical state (or material …

Comparative proteomic profiling reveals a pathogenic role for the O‐GlcNAcylated AIMP2–PARP1 complex in aging‐related hepatic steatosis in mice

R Li, Y Li, M Tian, H Zhang, L Lou, K Liu, J Zhang… - FEBS …, 2022 - Wiley Online Library
The prevalence of non‐alcoholic fatty liver disease (NAFLD) increases with aging. However,
the mechanism of aging‐related NAFLD remains unclear. Herein, we constructed an aging …