Necrotic reshaping of the glioma microenvironment drives disease progression
Glioblastoma is the most common primary brain tumor and has a dismal prognosis. The
development of central necrosis represents a tipping point in the evolution of these tumors …
development of central necrosis represents a tipping point in the evolution of these tumors …
Peptidomimetics in cancer targeting
The low efficiency of treatment strategies is one of the main obstacles to developing cancer
inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer …
inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer …
Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion
Background MicroRNAs (miRs) have been shown to play an important role in tumorigenesis,
including in head and neck squamous cell carcinoma (HNSCC). The miR-34 family is …
including in head and neck squamous cell carcinoma (HNSCC). The miR-34 family is …
The role of proprotein convertases in the regulation of the function of immune cells in the oncoimmune response
Proprotein convertases (PC) are a family of 9 serine proteases involved in the processing of
cellular pro-proteins. They trigger the activation, inactivation or functional changes of many …
cellular pro-proteins. They trigger the activation, inactivation or functional changes of many …
[HTML][HTML] Targeting options of tumor-associated macrophages (TAM) activity in gliomas
F Anagnostakis, C Piperi - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
Abstract Tumor-associated macrophages (TAMs), the most plastic cells of the hematopoietic
system, exhibit increased tumor-infiltrating properties and functional heterogeneity …
system, exhibit increased tumor-infiltrating properties and functional heterogeneity …
Pan-cancer analysis of FURIN as a potential prognostic and immunological biomarker
B Zhou, S Gao - Frontiers in molecular biosciences, 2021 - frontiersin.org
Background Furin is a calcium-dependent protease that processes various precursor
proteins through diverse secretory pathways. The deregulation of FURIN correlated with the …
proteins through diverse secretory pathways. The deregulation of FURIN correlated with the …
Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model
M Rodriguez-Perdigon, L Haeni… - … in Bioengineering and …, 2023 - frontiersin.org
The complex interaction between tumor-associated macrophages (TAMs) and tumor cells
through soluble factors provides essential cues for breast cancer progression. TAMs …
through soluble factors provides essential cues for breast cancer progression. TAMs …
DIMA: Data-driven selection of an imputation algorithm
J Egert, E Brombacher, B Warscheid… - Journal of Proteome …, 2021 - ACS Publications
Imputation is a prominent strategy when dealing with missing values (MVs) in proteomics
data analysis pipelines. However, it is difficult to assess the performance of different …
data analysis pipelines. However, it is difficult to assess the performance of different …
Therapeutic anti-glioma effect of the combined action of PCSK inhibitor with the anti-tumoral factors secreted by Poly (I: C)-stimulated macrophages
Macrophages plasticity is a key feature in cancer progression. Neoplastic cells can alter their
immune functions and orient them into a pro-tumoral phenotype. In this context, we …
immune functions and orient them into a pro-tumoral phenotype. In this context, we …
Inhibition of proprotein convertases activity results in repressed stemness and invasiveness of cancer stem cells in gastric cancer
A Zaafour, L Seeneevassen, TL Nguyen, C Genevois… - Gastric Cancer, 2024 - Springer
Background Gastric cancer (GC), the fourth leading cause of cancer-related death
worldwide, with most deaths caused by advanced and metastatic disease, has limited …
worldwide, with most deaths caused by advanced and metastatic disease, has limited …